BRD4 BD2 inhibitor ZX29

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Chemical Structure : BRD4 BD2 inhibitor ZX29

Catalog No.: PC-28677Not For Human Use, Lab Use Only.

BRD4 BD2 inhibitor ZX29 is a potent, BD2-selective BRD4 inhibitor with IC50 of 0.27 uM, SPR Kd of 1.68 uM, reduces cardiomyocyte death by inhibiting ferroptosis.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BRD4 BD2 inhibitor ZX29 is a potent, BD2-selective BRD4 inhibitor with IC50 of 0.27 uM, SPR Kd of 1.68 uM, reduces cardiomyocyte death by inhibiting ferroptosis.
ZX29 attenuates MI/RI and improves myocardial function in vivo.
ZX29 inhibits MI/RI-induced cardiac ferroptosis.
ZX29 inhibits the NCOA4-FTH1 pathway via BRD4 to attenuate cardiomyocyte ferroptosis.
ZX29 alleviates MI/RI-induced ferroptosis by inhibiting BRD4-YY1 interaction.
ZX29 preserves mitochondrial structural and functional homeostasis via BRD4 inhibition.

Physicochemical Properties

M.Wt	326.35
Formula	C19H18O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxy-2H-chromen-2-one

References

1. Zeyu Li, et al. Acta Pharm Sin B. 2026 Oct;16(10):6731-6755.

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