| Cat. No. |
Product Name |
Information |
| PC-28100 |
BPTF inhibitor BZ2
BPTF inhibitor
|
BPTF inhibitor BZ2 is a potent, high affinity, selective BPTF bromodomain inhibitor with Kd of 34 nM, inhibits the growth of SK-N-AS NB cells at concentrations ≥1 µM. |
| PC-28099 |
DC-BPi-07
BPTF inhibitor
|
DC-BPi-07 is a potent, high affinity, selective BPTF bromodomain inhibitor with IC50 of 16.0 nM. |
| PC-28098 |
DC-BPi-03
BPTF inhibitor
|
DC-BPi-03 is a potent small molecule BPTF bromodomain inhibitor with IC50 of 698 nM and SPR KD of 2.81 uM. |
| PC-28097 |
DC-BPi-11 hydrochloride
BPTF inhibitor
|
DC-BPi-11 hydrochloride is a potent, high affinity, selective BPTF bromodomain inhibitor with IC50 of 26.9 nM in HTRF assays and SPR KD of 20.7 nM, shows >100-fold selectivity over other BRD targets. |
| PC-28096 |
DC-BPi-11
BPTF inhibitor
|
DC-BPi-11 is a potent, high affinity, selective BPTF bromodomain with IC50 of 26.9 nM in HTRF assays and SPR KD of 20.7 nM, shows >100-fold selectivity over other BRD targets. |
| PC-28095 |
TP-238 hydrochloride
CECR2/BPTF inhibitor
|
TP-238 hydrochloride (TP238) is a potent, selective CECR2/BPTF bromodomains chemical probe inhibitor with IC50 of 30 nM against CECR2 and 350 nM against BPTF in an alphascreen assay, KD of 10 nM for CECR2 and 120 nM for BPTF in ITC assays. |
| PC-27999 |
ipAE1
BET BD2 inhibitor
|
ipAE1 is a highly potent, BD2-selective, covalent inhibitor of bromodomain and extra-terminal (BET) proteins with Kd of 0.092 nM for BRD4(2), has >1900-fold selectivity over BRD4(1), shows potent antiproliferative activity in MV4-11 cells with IC50 of 1.5 nM. |
| PC-27650 |
ARID1B inhibitor A-4
ARID1B inhibitor
|
ARID1B inhibitor A-4 is a selective small moelcule inhibitor of ARID1B, a subunit of the BRG1 (BRM)-associated factors (BAF) complex, binds to ARID1B DNA-binding domain. |
| PC-27364 |
KI-T28-03
TRIM28 inhibitor
|
KI-T28-03 is a selective small-molecule TRIM28 inhibitor that binds the TRIM28 PHD-bromodomain with ITC KD of 5 uM for full-length human TRIM28 protein, impairs leukemia cell proliferation and drives myeloid differentiation. |
| PC-27038 |
NHWD-870
BET inhibitor
|
NHWD-870 is a potent BET inhibitor with IC50 of 2.7 nM for BRD4 bromodomain, inhibits BRD4 activation and c-MYC expression. |
| PC-26818 |
LS-170
YEATS2 inhibitor
|
LS-170 is a potent, specific inhibitor of ATAC (Ada-two-A-containing) HAT complex subunit YEATS2 with IC50 of 0.14 uM (YEATS2 YEATS domain), shows no inhibitory effect for other YEATS domain family members, AF9, ENL and GAS41. |
| PC-26789 |
CZL-149
BET and p300/CBP inhibitor
|
CZL-149 is a highly potent, orally bioavailable dual inhibitor targeting BET and p300/CBP bromodomains with IC50 of 10.5 nM and 13 nM for p300 and BRD4 BD1 respectively. |
