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Chemical Structure : BRD4 inhibitor Compound V
Catalog No.: PC-35692Not For Human Use, Lab Use Only.
BRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively.
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BRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively; demonstrates reduction of c-Myc expression, inhibition of NF-κB signaling, and suppression of IL-8 production through potential synergistic inhibition of BRD4(1) and p38α.
| M.Wt | 442.542 | |
| Formula | C26H27FN6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Anand Divakaran, et al. J. Med. Chem., 2018, 61 (20), pp 9316-9334.
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