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Chemical Structure : BRD6851
Catalog No.: PC-62181Not For Human Use, Lab Use Only.
BRD6851 is a potent, cell-active Hedgehog (Hh) pathway inhibitor with IC50 of 0.4 uM against C3H10T1/2 cells undergoing Hh-induced activation acts predominantly as Smo antagonist.
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BRD6851 is a potent, cell-active Hedgehog (Hh) pathway inhibitor with IC50 of 0.4 uM against C3H10T1/2 cells undergoing Hh-induced activation acts predominantly as Smo antagonist; an allosteric inhibitor of SAG but a competitive inhibitor of purmorphamine-induced Gli1 expression.
| M.Wt | 489.393 | |
| Formula | C25H26Cl2N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dockendorff C, et al. ACS Med Chem Lett. 2012 Oct 11;3(10):808-813.
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