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Chemical Structure : BRD8 inhibitor DN01
Catalog No.: PC-38761Not For Human Use, Lab Use Only.
BRD8 inhibitor DN01 is a first-in-class selective and cellularly active probe for NuA4 factor BRD8 (BD1) with AlphaScreen IC50 of 12 nM, displays IC50 of 0.21 uM in-cell engagement within BRET displacement assays, shows no affinity for BRD8 (BD2), CBP, and p300.
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BRD8 inhibitor DN01 is a first-in-class selective and cellularly active probe for NuA4 factor BRD8 (BD1) with AlphaScreen IC50 of 12 nM, displays IC50 of 0.21 uM in-cell engagement within BRET displacement assays, shows no affinity for BRD8 (BD2), CBP, and p300.
| M.Wt | 370.424 | |
| Formula | C21H23FN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. David Remillard, et al. ACS Chem Biol. 2021 Nov 19;16(11):2185-2192.
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