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BRD9526

Chemical Structure : BRD9526

CAS No.: 1446352-30-2

BRD9526 (BRD 9526)

Catalog No.: PC-62852Not For Human Use, Lab Use Only.

BRD9526 is a potent, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 60 nM, partially lowers Gli1 expression at concentrations of 10 uM, a useful probe of Shh signaling pathway. .

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BRD9526 is a potent, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 60 nM, partially lowers Gli1 expression at concentrations of 10 uM, a useful probe of Shh signaling pathway.

    Physicochemical Properties

    M.Wt 584.509
    Formula C26H31Cl2N3O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    Cyclopropanecarboxamide, N-[(2R,3S)-2-[[[(2,4-dichlorophenyl)sulfonyl]methylamino]methyl]-3,4,5,6-tetrahydro-5-[(1R)-2-hydroxy-1-methylethyl]-3-methyl-6-oxo-2H-1,5-benzoxazocin-10-yl]-

    References

    1. Schaefer GI, et al. J Am Chem Soc. 2013 Jul 3;135(26):9675-80.

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