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Request The Product List ofHedgehog (Hh) Hedgehog (Hh)

Cat. No. Product Name CAS No. Information
PC-60477

TAK-441

1186231-83-3

A highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays; suppresses transcription factor Gli1 mRNA expression in tumor-associated stromal tissue and inhibits tumor growth in mouse medulloblastoma allograft model.

Solid Tumors

Phase 1 Discontinued

PC-70165

RUSKI-201

1458031-48-5

A potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM; blocks Hh signaling in H520, Panc-1, and MCF-7 coculture with Shh-Light2 cells (IC50=4.8 uM, 7.8 uM, and 8.5 uM, respectively); selectively inhibits Hh palmitoylation over a panel of >100 palmitoylated substrates in cells.

PC-45464

RU-SKI 43 hydrochloride

A small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM; specific to Shh palmitoylation and no effect for palmitoylation of H-Ras, Fyn and myristoylation of c-Src; reduces pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling, inhibits two key proliferative pathways regulated by Akt and mTOR.

PC-45463

RU-SKI 43

1043797-53-0

A small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM; specific to Shh palmitoylation and no effect for palmitoylation of H-Ras, Fyn and myristoylation of c-Src; reduces pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling, inhibits two key proliferative pathways regulated by Akt and mTOR.

PC-42258

Ciliobrevin A

302803-72-1

A small molecule Hedgehog pathway inhibitor (IC50=7 uM) that acts downstream of Su(fu) to modulate Gli processing, activation or trafficking; does not directly target Smo, blocks the proliferation of cerebellar granule neuron precursors expressing an oncogenic form of Smo; disrupts spindle pole assembly and kinetochore-microtubule attachment, inhibits melanosome aggregation and peroxisome motility in cultured cells; inhibits AAA+ ATPase motor cytoplasmic dynein.

PC-45147

Cyclopamine

4449-51-8

A natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM; inhibits hedgehog-dependent expression of Pax7 with IC50 of 24 nM, blocks the response of neural plate explants to recombinant Shh-N; A useful tool in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.

PC-63064

Cyclopamine tartrate

1178510-81-0 Cyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM; inhibits hedgehog-dependent expression of Pax7 with IC50 of 24 nM, blocks the response of neural plate explants to recombinant Shh-N; A useful tool in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.

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