BRL-37344 sodium (BRL 37344A) is a potent and selective β3 adrenoceptor (β3AR) agonist with Ki of 287 nM.
BRL-37344 has weaker binding affinity for β1 and β2 receptors with Ki of 1750 and 1120 nM, respectively.
BRL-37344 is a potent agonist in brown adipocytes (EC50 = 3.3 +/- 0.8 nM) than in white adipocytes (EC50=5.7 nM) or colon (EC50=27.5 nM).
BRL-37344 stimulates fuel oxidation by soleus muscle in vitro.
Physicochemical Properties
M.Wt
385.82
Formula
C19H21NO4ClNa
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Rel-2-[4-[(2S)-2-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]-acetic acid, monosodium salt
References
1. Arch JR, et al. Nature. 1984 May 10-16;309(5964):163-5.
