You are here:Home-Inhibitors & Agonists-GPCR-Adrenergic Receptor

Request The Product List ofAdrenergic Receptor Adrenergic Receptor

Cat. No. Product Name CAS No. Information
PC-35360

AGN192836

171102-29-7 AGN192836 (AGN 192836) is a potent, selective α2 adrenergic (alpha 2-adrenoceptor) agonist with EC50 of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively; displays 1200-, 50- and 10-fols selectivity for the α2A-receptor, α2B-receptor, and α2C-receptors relative to the α2C-receptors; demonstrates effectivity for the reduction of intraocular pressure and for the reduction of blood pressure in vivo.
PC-35028

BI 167107

1202235-68-4 BI 167107 is a highly potent agonist of the β2 adrenergic receptor (β2AR) and β1AR (IC50=3.2 nM) and shows some activity as α1A antagonist (IC50 = 32 nM); due to its high potency and slow dissociation from the target BI-167107 was subsequently used to support crystallization of active state β2AR and β2AR-G-protein complexes.
PC-43177

Midodrine hydrochloride

43218-56-0 Midodrine is a selective α1-adrenoceptor agonist that acts as a vasopressor/antihypotensive agent for the treatment of dysautonomia and orthostatic hypotension; activates the alpha-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure; does not stimulate cardiac beta-adrenergic receptors, and diffuses poorly across the blood-brain barrier.

Hypertension

Approved

PC-43176

Midodrine

42794-76-3 Midodrine is a selective α1-adrenoceptor agonist that acts as a vasopressor/antihypotensive agent for the treatment of dysautonomia and orthostatic hypotension; activates the alpha-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure; does not stimulate cardiac beta-adrenergic receptors, and diffuses poorly across the blood-brain barrier.

Hypertension

Approved

PC-43161

Yohimbine

146-48-5 Yohimbine is an indole alkaloid that has high affinity for the α2-adrenergic receptors with Ki of 1 nM for α2A, α2B and α2C; shows moderate affinity for the α1 receptor, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, 5-HT2B, and D2 receptors, and weak affinity for the 5-HT1E, 5-HT2A, 5-HT5A, 5-HT7, and D3 receptors.
PC-43012

Atipamezole

104054-27-5 Antipamezole (MPV-1248) is a potent, specific α2-adrenoceptor antagonist with Ki of 1.6 nM; reverses the effects of the sedative dexmedetomidine and medetomidine as a veterinary drug.

Alcoholism

Phase 1 Discontinued

PC-43011

Atipamezole hydrochloride

104075-48-1 Antipamezole (MPV-1248) is a potent, specific α2-adrenoceptor antagonist with Ki of 1.6 nM; reverses the effects of the sedative dexmedetomidine and medetomidine as a veterinary drug.

Alcoholism

Phase 1 Discontinued

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:
Contact Us sales@probechem.com