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Chemical Structure : BS-194
CAS No.: 1092443-55-4
Catalog No.: PC-61917Not For Human Use, Lab Use Only.
BS-194 (BS194) is a potent, selective, orally bioactive CDK2 inhibitor with IC50 of 2.4 nM, displays 140-fold selectivity over CDK7 (IC50=378 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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BS-194 (BS194) is a potent, selective, orally bioactive CDK2 inhibitor with IC50 of 2.4 nM, displays 140-fold selectivity over CDK7 (IC50=378 nM).
BS-194 weakly inhibits CDK1, CDK5, CDK7, and CDK9 with IC50 of 30, 30, 250, and 90 nM.
BS-194 shows inhibition of the phosphorylation of CDK substrates, Rb and the RNA polymerase II C-terminal domain, down-regulation of cyclins A, E, and D1, and cell cycle block in the S and G2/M phases.
BS-194 inhibits human tumor xenografts and suppresses CDK substrate phosphorylation.
| M.Wt | 385.468 | |
| Formula | C20H27N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S,3S)-3-[[7-(benzylamino)-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]butane-1,2,4-triol |
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1. Hazel P, et al. ChemMedChem. 2017 Mar 7;12(5):372-380.
2. Tripathi SK, et al. J Mol Recognit. 2012 Oct;25(10):504-12.
3. Heathcote DA, et al. J Med Chem. 2010 Dec 23;53(24):8508-22.
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