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Chemical Structure : BVT-948
CAS No.: 39674-97-0
Catalog No.: PC-62676Not For Human Use, Lab Use Only.
BVT-948 (SPS8I-3) is a noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) with IC50 of 0.09-1.7 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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BVT-948 (SPS8I-3) is a noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) with IC50 of 0.09-1.7 uM.
BVT-948 (SPS8I-3) also inhibits the protein methyltransferases SETD8, SETD2, G9a, SMYD2, CARM1, and PRMT3 with IC50 of 0.7-3.2 uM.
BVT-948 (SPS8I-3) enhances insulin signaling in cells and insulin tolerance in ob/ob mice.
BVT-948 (SPS8I-3) suppresses the expression of matrix metalloproteinase-9 and invasion in breast cancer cells.
| M.Wt | 241.2 | |
| Formula | C14H11NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO; 100 mg/mL |
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| Chemical Name/SMILES |
4-hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione |
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1. Blum G, et al. ACS Chem Biol. 2014 Nov 21;9(11):2471-8.
2. Hwang BM, et al. BMB Rep. 2013 Nov;46(11):533-8.
3. Liljebris C, et al. J Pharmacol Exp Ther. 2004 May;309(2):711-9.
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