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Bardoxolone

Chemical Structure : Bardoxolone

CAS No.: 218600-44-3

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Bardoxolone (CDDO, RTA401 ,RTA-401)

Catalog No.: PC-25722Not For Human Use, Lab Use Only.

Bardoxolone (RTA401, CDDO) is a covalent, orally active activator of NRF2, also inhibits SARS-CoV-2 3CL protease (EC50=0.43 uM), also inhibits necroptosis in HT-29 cells by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3.

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10 mg $78 In stock
50 mg $148 In stock
100 mg $248 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Bardoxolone (RTA401, CDDO) is a covalent, orally active activator of NRF2, also inhibits SARS-CoV-2 3CL protease (EC50=0.43 uM), also inhibits necroptosis in HT-29 cells by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3.

Physicochemical Properties

M.Wt 491.67
Formula C31H41NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-Cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicene-4a(2H)-carboxylic acid

References

1. Sun Q, et al. Signal Transduct Target Ther. 2021 May 29;6(1):212.

2. Wang Y, et al. Eur J Med Chem. 2021 Feb 15;212:113030.

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