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Chemical Structure : Baricitinib
CAS No.: 1187594-09-7
Catalog No.: PC-73190Not For Human Use, Lab Use Only.
Baricitinib (LY3009104, INCB028050) is a potent, selective and orally bioavailable JAK1/JAK2 inhibitor with IC50 of 5.9/5.7 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $98 | In stock | |
| 50 mg | $168 | In stock | |
| 100 mg | $298 | In stock | |
| 200 mg | $498 | In stock | |
| 1 g | Get quote |
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Baricitinib (LY3009104, INCB028050) is a potent, selective and orally bioavailable JAK1/JAK2 inhibitor with IC50 of 5.9/5.7 nM, respectively.
Baricitinib (LY3009104, INCB028050) shows moderate selectivity against Tyk2 (IC50=53 nM) and 100-fold selectivity over JAK3.
INCB028050 inhibited IL-6–stimulated phosphorylation of the canonical substrate STAT3 (pSTAT3) and subsequent production of the chemokine MCP-1 with IC50 values of 44 nM and 40 nM, respectively, in PBMCs.
Baricitinib (LY3009104, INCB028050) suppressed phosphorylated STAT3 in the peripheral blood of rAIA animals.
Baricitinib (LY3009104, INCB028050) (10 mg/kg) reduces elevated cytokine mRNA levels in draining lymph nodes from rats with AIA.
| M.Wt | 371.42 | |
| Formula | C16H17N7O2S | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Fridman JS, et al. J Immunol. 2010 May 1;184(9):5298-307.
2. Migita K, et al. Clin Exp Immunol. 2013 Dec;174(3):356-63.
3. Genovese MC, et al. N Engl J Med. 2016 Mar 31;374(13):1243-52.
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