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Chemical Structure : Belizatinib
Catalog No.: PC-70256Not For Human Use, Lab Use Only.
A potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM.
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A potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM; exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models.
Blood Cancer
Phase 2 Clinical
| M.Wt | 577.745 | |
| Formula | C33H44FN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sullivan I, et al. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.
2. Iams WT, et al. Cancer J. 2015 Sep-Oct;21(5):378-82.
3. Khotskaya YB, et al. Pharmacol Ther. 2017 May;173:58-66.
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