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Benfotiamine

Chemical Structure : Benfotiamine

CAS No.: 22457-89-2

Benfotiamine (S-Benzoylthiamine O-monophosphate)

Catalog No.: PC-45197Not For Human Use, Lab Use Only.

A synthetic S-acyl derivative of thiamine (vitamin B1) that possesses anti-inflammatory effects.

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Biological Activity

A synthetic S-acyl derivative of thiamine (vitamin B1) that possesses anti-inflammatory effects; upregulates antioxidative system in activated BV-2 microglia cells; significantly improves the cognitive abilities of mild to moderate AD patients independently of brain amyloid accumulation.

Physicochemical Properties

M.Wt 466.4479
Formula C19H23N4O6PS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzenecarbothioic acid, S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] ester

References

1. Bozic I, et al. Front Cell Neurosci. 2015 Sep 4;9:351.

2. Pan X, et al. Neurosci Bull. 2016 Dec;32(6):591-596.

3. Bozic I, et al. PLoS One. 2015 Feb 19;10(2):e0118372.

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