Catalog No.: PC-26655Not For Human Use, Lab Use Only.
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase, disrupts G-quadruplex (G4)-STAT1 interaction and synergizes with olaparib to drive cancer cell death, shows antineoplastic properties, also is a potent USP22 inhibitor, effectively suppresses Wnt pathway activation and CRC cell proliferation
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase, disrupts G-quadruplex (G4)-STAT1 interaction and synergizes with olaparib to drive cancer cell death, shows antineoplastic properties, also is a potent USP22 inhibitor, effectively suppresses Wnt pathway activation and CRC cell proliferation.
Berberine also acts as a natural molecular glue degrader of Hypoxia-Inducible Factor 1 Alpha (HIF1α), directly binds HIF1α at E816, stabilizing its interaction with the E3 ubiquitin ligase TRIM28, which subsequently promotes K48-linked ubiquitination of HIF1α.
