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Berotralstat

Chemical Structure : Berotralstat

CAS No.: 1809010-50-1

Berotralstat (BCX7353, BCX-7353)

Catalog No.: PC-36087Not For Human Use, Lab Use Only.

Berotralstat (BCX7353, BCX-7353) is a potent, highly selective, oral plasma kallikrein inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Berotralstat (BCX7353, BCX-7353) is a potent, highly selective, oral plasma kallikrein inhibitor.
Berotralstat (BCX7353) displays high selectivity over other structurally related serine proteases.
Berotralstat (BCX7353) is the first orally bioavailable prophylactic treatment for hereditary angioedema (HAE) attacks.

Physicochemical Properties

M.Wt 562.573
Formula C30H26F4N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-[3-(aminomethyl)phenyl]-N-(5-{(R)-(3-cyanophenyl)[(cyclopropylmethyl)amino]methyl}-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

References

1, Kotian PL, et al. J Med Chem. 2021 Sep 9;64(17):12453-12468.
2, Aygören-Pürsün E, et al. N Engl J Med. 2018 Jul 26;379(4):352-362.
3, Farkas H, et al. Clin Transl Allergy. 2021 Jun;11(4):e12035.
4, Zuraw B, et al. J Allergy Clin Immunol. 2021 Jul;148(1):164-172.e9.

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