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CB-002

Chemical Structure : CB-002

CAS No.: 61034-15-9

CB-002 (CB002)

Catalog No.: PC-60218Not For Human Use, Lab Use Only.

CB-002 (CB002) is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CB-002 (CB002) is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts.
CB-002 (CB002) increases expression of endogenous p53 target genes NOXA, DR5, and p21 and cell death.
CB-002 (CB002) decreases the stability of mutant p53 in RXF393 cancer cells and an exogenously expressed R175H p53 mutant in HCT116 p53-null cells.

Physicochemical Properties

M.Wt 271.28
Formula C13H13N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

8-Anilino-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

References

1. Hernandez-Borrero LJ, et al. Cell Cycle. 2017 Jul 27:0. doi: 10.1080/15384101.2017.1346762.

2. Richardson C, et al. Cell Cycle. 2017 Jul 27:0. doi: 10.1080/15384101.2017.1356514.

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