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CBK034026C

Chemical Structure : CBK034026C

CAS No.:

CBK034026C

Catalog No.: PC-49150Not For Human Use, Lab Use Only.

CBK034026C is a small molecule targeting metabolic vulnerabilities caused by N-acetyltransferase 2 (NAT2) activity, exhibits specific toxicity towards colorectal cancer (CRC) cells with high NAT2 activity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CBK034026C is a small molecule targeting metabolic vulnerabilities caused by N-acetyltransferase 2 (NAT2) activity, exhibits specific toxicity towards colorectal cancer (CRC) cells with high NAT2 activity.
CBK034026C activated the Nf-kB pathway, which is similar to ouabain, a potent inhibitor of the Na+/K+-ATPase.

Physicochemical Properties

M.Wt 468.583
Formula C23H31F3N4OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(((1-butylpiperidin-4-yl)methyl)amino)-N-cyclobutyl-7-(trifluoromethyl)thieno[3,2-b]pyridine-3-carboxamide

References

1. Xiaonan Zhang, et al. Biochem Pharmacol. 2022 Jul 21;115184.

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