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CBP bromodomain inhibitor 17

Chemical Structure : CBP bromodomain inhibitor 17

CAS No.: 2161356-61-0

CBP bromodomain inhibitor 17 (CBP-IN-17)

Catalog No.: PC-63543Not For Human Use, Lab Use Only.

CBP-IN-17 is a potent, selective CBP bromodomain inhibitor with IC50 of 69 nM, displays exquisite selectivity over BRD4(1) (IC50=18 uM) and the broader bromodomain family.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CBP-IN-17 is a potent, selective CBP bromodomain inhibitor with IC50 of 69 nM, displays exquisite selectivity over BRD4(1) (IC50=18 uM) and the broader bromodomain family.

    Physicochemical Properties

    M.Wt 426.486
    Formula C22H20F2N4OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-3-methylbenzo[d]thiazol-2(3H)-one

    References

    1. Bronner SM, et al. J Med Chem. 2017 Dec 28;60(24):10151-10171.

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