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Chemical Structure : CC-3240
Catalog No.: PC-21444Not For Human Use, Lab Use Only.
CC-3240 is a molecular glue degrader of CaMKK2 based on CC-8977 with bingding IC50 of 9 nM and DC50 of 100 nM (THP1 cells, Dmax=92%).
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CC-3240 is a molecular glue degrader of CaMKK2 based on CC-8977 with bingding IC50 of 9 nM and DC50 of 100 nM (THP1 cells, Dmax=92%).
CC-3240 inhibits pAMPK in A427 cells with an IC50 of 201 nM, without deleterious effects on cell health.
CC-3240 can potently and selectively inhibits and degrades CaMKK2 in vitro and in vivo.
CC-3240 increases T cell activation in myeloid/T cell cocultures and decreases migration of tumor cells.
| M.Wt | 917.18 | |
| Formula | C52H64N6O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Young Chen, et al. Journal of Medicinal Chemistry 2023.
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