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CC-885

Chemical Structure CC-885

CAS No.: 1010100-07-8

CC-885 (CC 885;CC885)

Catalog No.: PC-60125Not For Human Use, Lab Use Only.

CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1.

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Biological Activity

CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1; The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1; promotes both the in vivo and in vitro ubiquitination of GSPT1 by cereblon and decreases the protein half-life of GSPT1.

Physicochemical Properties

M.Wt 440.9
Formula C22H21ClN4O4
CAS No. 1010100-07-8
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name

N-(3-chloro-4-methylphenyl)-N'-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-urea

Clinical Information

References

1. Collins I, et al. Biochem J. 2017 Mar 15;474(7):1127-1147.

2. Matyskiela ME, et al. Nature. 2016 Jul 14;535(7611):252-7.

3. Hansen JD, et al. J Med Chem. 2017 Apr 13. doi: 10.1021/acs.jmedchem.6b01911.

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