Chemical Structure : CC10137
CAS No.:
3061967-46-9
CC10137
(CC-10137)
Catalog No.: PC-27359Not For Human Use, Lab Use Only.
CC10137 is a potent, orally bioavailable, peripherally restricted α2A-adrenergic receptor (α2AAR) agonist with Ki of 6.0 nM, exhibits potent α2AAR agonist activity (EC50=13.1 nM) in HEK293T cells co-transfected with α2AAR and Gα15 plasmids.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CC10137 is a potent, orally bioavailable, peripherally restricted α2A-adrenergic receptor (α2AAR) agonist with Ki of 6.0 nM, exhibits potent α2AAR agonist activity (EC50=13.1 nM) in HEK293T cells co-transfected with α2AAR and Gα15 plasmids.
CC10137 shows a stronger binder for α2AAR than clonidine or tizanidine.
CC10137 does not induce sedation, hypotension, hypothermia, and impairment of the tail-flick reflexes in mice.
CC10137 does not impair the spinal nociceptive reflex.
CC10137 demonstrates α2AR-dependent efficacy and broad synergistic potential in a neuropathic pain model.
CC10137 demonstrated dose-dependent, synergistic, and long-lasting anti-allodynia in cancer pain models.
Physicochemical Properties
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M.Wt
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355.46
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Formula
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C19H21N3O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-N-(3-((2,3-dimethylphenyl)(1H-imidazol-4-yl)methyl)phenyl)methanesulfonamide
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References
1. Cheng Z, et al. Cell Rep Med. 2026 Jul 21;7(7):102864.
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