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Chemical Structure : CCG-203586
Catalog No.: PC-61426Not For Human Use, Lab Use Only.
A potent, CNS-active Glucosylceramide synthase (GCS) inhibitor with IC50 of 27 nM.
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A potent, CNS-active Glucosylceramide synthase (GCS) inhibitor with IC50 of 27 nM; inhibits GlcCer production in whole wild-type MDCKII cells with IC50 of 15.3 nM, has little to no apparent recognition by MDR1; significantly and dose-dependently decreases brain glucosylceramide content after intraperitoneal administration in mice.
| M.Wt | 436.552 | |
| Formula | C26H32N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Larsen SD, et al. J Lipid Res. 2012 Feb;53(2):282-91.
2. Arthur JR, et al. Neurochem Res. 2013 Apr;38(4):866-75.
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