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Chemical Structure : CCG-63802
CAS No.: 620112-78-9
Catalog No.: PC-45955Not For Human Use, Lab Use Only.
A reversible, allosteric inhibitor of regulator of G-protein signaling (RGS) proteins with a potency order of RGS4 > 19 = 16 > 8 >> 7.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $360 | In stock |
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A reversible, allosteric inhibitor of regulator of G-protein signaling (RGS) proteins with a potency order of RGS4 > 19 = 16 > 8 >> 7; inhibits the Gαo-RGS4 interaction with IC50 of 1.9 uM, does not inhibit Gα binding to RGS7, 2- to 10-fold more potent at RGS4 than on the other closely related R4 family members, RGS8 and RGS16; decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling in PSNL rats.
| M.Wt | 450.5117 | |
| Formula | C26H18N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Benzothiazoleacetonitrile, .alpha.-[[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]- |
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1. Blazer LL, et al. Mol Pharmacol. 2010 Sep;78(3):524-33.
2. Bosier B, et al. Br J Pharmacol. 2015 Nov;172(22):5333-46.
3. Dobrivojević M, et al. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1260-8.
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