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Chemical Structure : CCT241533
CAS No.: 1262849-73-9
Catalog No.: PC-44032Not For Human Use, Lab Use Only.
CCT241533 is a potent and selective ATP-competitive inhibitor of CHK2 with IC50 of 3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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CCT241533 is a potent and selective ATP-competitive inhibitor of CHK2 with IC50 of 3 nM.
CCT241533 shows good selectivity for CHK2 against CHK1 (IC50=180 nM) and a wider panel of kinases and with promising in vitro ADMET properties.
CCT241533 inhibits CHK2 autophosphorylation at S516, band shift mobility changes, and HDMX degradation.
| M.Wt | 442.4833 | |
| Formula | C23H27FN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Pyrrolidinemethanol, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-, (3R,4S)- |
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1. Caldwell JJ, et al. J Med Chem. 2011 Jan 27;54(2):580-90.
2. Anderson VE, et al. Cancer Res. 2011 Jan 15;71(2):463-72.
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