CCT400028 | Aurora A PROTAC | Probechem Biochemicals

Chemical Structure : CCT400028

CCT400028 (CCT-400028)

Catalog No.: PC-26015Not For Human Use, Lab Use Only.

CCT400028 is a second-generation alisertib-derived Aurora A PROTAC with DC50 of 29 nM in MV4-11 leukemia cells, D max=85%, shows excellent selectivity in proteomic and kinase selectivity profiling.

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Biological Activity

CCT400028 is a second-generation alisertib-derived Aurora A PROTAC with DC50 of 29 nM in MV4-11 leukemia cells, D max=85%, shows excellent selectivity in proteomic and kinase selectivity profiling.

Physicochemical Properties

M.Wt	878.40
Formula	C47H49ClFN7O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)-N-(5-((5-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenoxy)pentyl)oxy)pentyl)-2-methoxybenzamide

References

1. O'Hanlon JA, et al. J Med Chem. 2026 Jan 22;69(2):1552-1567.

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CCT400028 (CCT-400028)

Biological Activity

Physicochemical Properties

References

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