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Chemical Structure : CD147 inhibitor AC-73
CAS No.: 775294-71-8
Catalog No.: PC-49041Not For Human Use, Lab Use Only.
AC-73 is a potent, specific small molecule inhibitor of CD147 (Response Units=63, SPR assays), AC-73 disrupts CD147 dimerization and inhibits the motility and invasion of hepatocellular carcinoma cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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AC-73 is a potent, specific small molecule inhibitor of CD147 (Response Units=63, SPR assays), AC-73 disrupts CD147 dimerization and inhibits the motility and invasion of hepatocellular carcinoma cells.
AC-73 significantly decreased the migration ability of SMMC-7721 cells in a dose-dependent manner in in vitro scratch assays, decreased the invasion of HCC cells with IC50 of 10.19 μM for SMMC-7721 and 7.16 μM for Huh-7, respectively.
AC-73 inhibits the invasion of HCC cells by reducing MMP-2 production through blocking CD147-stimulated MAPK/STAT3 signaling.
AC-73 (25 mg/kg, 50 mg/kg, intrahepatic injection) reduced tumor metastasis by affecting the CD147/ERK1/2/STAT3 pathways in orthotopic HCC transplant nude mouse model, with low toxicity and well tolerance in nude mice.
AC-73 likely binds to the dimer interface of CD147, the N-terminal IgC2 domain of CD147.
| M.Wt | 319.4 | |
| Formula | C21H21NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-{2-[(Biphenyl-4-ylmethyl)-amino]-1-hydroxy-ethyl}-phenol |
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1. Spinello I, et al. Haematologica. 2019 May;104(5):973-985.
2. Fu ZG, et al. Oncotarget. 2016 Feb 23;7(8):9429-47.
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