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Chemical Structure : CDEAH
Catalog No.: PC-21025Not For Human Use, Lab Use Only.
CDEAH is a monofunctional alkylating agent that selectively kills PARP1- and xeroderma pigmentosum A-deficient cells.
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CDEAH is a monofunctional alkylating agent that selectively kills PARP1- and xeroderma pigmentosum A-deficient cells.
CDEAH preferentially alkylates guanine nucleobases, forming DNA adducts that can be removed from DNA by either a PARP1-dependent base excision repair or nucleotide excision repair.
CDEAH treatment leads to the formation of strand breaks, an accumulation of cells in S phase and activation of the DNA damage response.
CDEAH selectively inhibits PARP1-deficient xenograft tumor growth compared to isogenic PARP1-proficient tumors.
| M.Wt | 172.09 | |
| Formula | C6H15Cl2N | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Minwoo Wie, et al. NAR Cancer. 2023 Aug 7;5(3):zcad042.
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