An alkylating agent used to treat cancer that has been previously used in the palliation of a wide variety of neoplastic diseases.
An alkylating agent used as a treatment of some brain cancers, astrocytoma and glioblastoma; a prodrug and an imidazotetrazine derivative of the alkylating agent dacarbazine.
A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities; used to treat cancers and autoimmune diseases.
A small molecule DNA intercalater with antineoplastic activity, does not exhibit cardiotoxicity compared with doxorubicin; induces both protein-associated DNA single-strand breaks and DNA-protein crosslinks in cancer cells.
A potent and selective hypoxia-activated phosphoramidate DNA cross-linking mustard; selectively potent under hypoxia and stable to liver microsomes; inhibits H246 cells and HT29 cells with IC50 of 0.1 uM and 0.2 uM respectively; active in an in vivo MIA PaCa-2 pancreatic cancer orthotopic xenograft model.
Phase 3 Clinical
A platinum-based antineoplastic agent that works by blocking the duplication of DNA; forms both inter- and intra-strand cross links in DNA, prevents DNA replication and transcription, causing cell death.
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