CDK2 degrader 37

Chemical Structure : CDK2 degrader 37

Catalog No.: PC-25360Not For Human Use, Lab Use Only.

CDK2 degrader 37 is a potent, orally bioavailable and selective degrader of CDK2 with DC50 of 17 nM in CCNE1nonamp TOV21G cell line, >100-fold selectivity over CDK1, and >500-fold selectivity over CDK9.

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Biological Activity

Physicochemical Properties

M.Wt	852.90
Formula	C39H46F6N8O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(3S,4R)-1-[[1-[4-(2,6-Dioxo-3-piperidyl)-2-fluoro-phenyl]-4-piperidyl]methyl]-3-fluoro-4-piperidyl]-3-fluoro-4-[[4-[(3S)-3-hydroxy-3-methyl-1-piperidyl]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzenesulfonamide

References

1. Collier PN, et al. J Med Chem. 2025 Aug 20. doi: 10.1021/acs.jmedchem.5c01160.

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CDK2 degrader 37

Biological Activity

Physicochemical Properties

References

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