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Chemical Structure : CE3F4
CAS No.: 143703-25-7
Catalog No.: PC-63111Not For Human Use, Lab Use Only.
CE3F4 is a potent, noncompetitive EPAC1 inhibitor that blocks EPAC1-induced Rap1 activation both in cell-free systems and in intact cells and did not influence protein kinase A holoenzyme activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $158 | In stock | |
| 100 mg | $388 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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CE3F4 is a potent, noncompetitive EPAC1 inhibitor that blocks EPAC1-induced Rap1 activation both in cell-free systems and in intact cells and did not influence protein kinase A holoenzyme activity.
CE3F4 reduces the exchange activity of Epac1 induced by 007 (2 uM) with IC50 of 23 uM.
CE3F4 is a useful pharmacological tools for determining the biological functions of EPAC1 in a wide range of biological processes.
| M.Wt | 351.01 | |
| Formula | C11H10Br2FNO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde |
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1. Courilleau D, et al. J Biol Chem. 2012 Dec 28;287(53):44192-202.
2. Courilleau D, et al. Biochem Biophys Res Commun. 2013 Oct 25;440(3):443-8.
3. Brown LM, et al. J Biol Chem. 2014 Mar 21;289(12):8217-30.
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