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Chemical Structure : CFM-4.16
Catalog No.: PC-35499Not For Human Use, Lab Use Only.
CFM-4.16 is a CARP-1 functional mimetic (CFM) compound bind with CARP-1, stimulates CARP-1 expression and apoptosis.
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CFM-4.16 is a CARP-1 functional mimetic (CFM) compound bind with CARP-1, stimulates CARP-1 expression and apoptosis; attenuates the activation of STAT3, a transducer of signaling following activation of the EGFR and Src TKs; robustly inhibits oncogenic intracellular kinase Akt activity and/or expression in wild-type HCC 827, H1975 and H23 NSCLC cells (Figure 2A, 2B, and Supplementary Figure 1A). CFM-4.16 also inhibited Akt activation in erlotinib and gemcitabine-resistant, but not in osimertinib-resistant, NSCLC cells; causes superior inhibition of viability of TNBC cells when used in combination with doxorubicin.
| M.Wt | 440.342 | |
| Formula | C22H15Cl2N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cheriyan VT, et al. Oncotarget. 2018 Jul 3;9(51):29680-29697.
2. Cheriyan VT, et al. Oncotarget. 2016 Nov 8;7(45):73370-73388.
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