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Chemical Structure : CFMB
Catalog No.: PC-72422Not For Human Use, Lab Use Only.
CFMB (FFA2R agonist 58) is a potent, allosteric FFAR2 (GPR43) agonist/modulator.
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CFMB (FFA2R agonist 58) is a potent, allosteric FFAR2 (GPR43) agonist/modulator.
FFA2R agonist 58 functions as a positive/priming modulator in these cells by turning the natural FFA2R agonist acetate into a potent activator of the neutrophil NADPH-oxidase.
FFA2R agonist 58 lowers the concentration of acetate required to induce a transient rise in the concentration of intracellular Ca2+ in neutrophils, has no direct effect on the neutrophil NADPH-oxidase activity but affects the response induced by acetate.
FFA2R agonist 58 significantly reduced the amount of internalized influenza A virus (IAV) in treated A549 cells.
| M.Wt | 384.922 | |
| Formula | C21H21ClN2OS | |
| Appearance | Solid | |
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1. Jonas Mårtensson, et al. J Leukoc Biol. 2018 Dec;104(6):1117-1132.
2. Guangwen Wang, et al. J Virol. 2020 Jan 6;94(2):e01707-19.
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