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CGP-42112

Chemical Structure CGP-42112

CAS No.: 127060-75-7

CGP-42112 (CGP42112;CGP 42112;CGP-42112A;CGP42112A;CGP 42112A)

Catalog No.: PC-43020Not For Human Use, Lab Use Only.

CGP-42112 (CGP42112A) is a highly potent, selective Angiotensin-II subtype 2 receptor(AT2 receptor) agonist with Ki of 0.24 nM.

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5 mg $358 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CGP-42112 (CGP42112A) is a highly potent, selective Angiotensin-II subtype 2 receptor(AT2 receptor) agonist with Ki of 0.24 nM; significantly inhibits cGMP production from the basal value, also significantly inhibits TH-enzyme activity from the basal value in cultured porcine adrenal medullary cells; antagonizes Ang-II induced contractions in rabbit aortic rings with IC50 of 1.85 uM.

Physicochemical Properties

M.Wt 1052.185
Formula C52H69N13O11
CAS No. 127060-75-7
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

DMSO: ≥ 350 mg/mL

Chemical Name

L-Isoleucine, N-(3-pyridinylcarbonyl)-L-tyrosyl-N6-[N2-[(phenylmethoxy)carbonyl]-L-arginyl]-L-lysyl-L-histidyl-L-prolyl-

Clinical Information

References

1. Hakam AC, et al. Am J Physiol Renal Physiol. 2006 Jun;290(6):F1430-6.

2. Takekoshi K, et al. Biochem Biophys Res Commun. 2000 Jun 7;272(2):544-50.

3. Näveri L, et al. J Cereb Blood Flow Metab. 1994 Jan;14(1):38-44.

4. Näveri L, et al. Acta Physiol Scand Suppl. 1995;630:1-48.

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