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Chemical Structure : CH24H inhibitor 17
Catalog No.: PC-38337Not For Human Use, Lab Use Only.
CH24H inhibitor 17 is a potent, highly selective, BBB permeable inhibitor of Cholesterol 24-hydroxylase (CH24H/CYP46A1) with IC50 of 8.5 nM.
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CH24H inhibitor 17 is a potent, highly selective, BBB permeable inhibitor of Cholesterol 24-hydroxylase (CH24H/CYP46A1) with IC50 of 8.5 nM.
CH24H inhibitor 17 shows excellent selectivity for CYP3A4 as well as CYP2C8, CYP2C9, and CYP2D6 (IC50>10 uM).
CH24H inhibitor 17 reduces 24S-hydroxycholesterol levels in the mouse brain when oral administration treatment with 17 at 30 mg/kg for 3 days.
| M.Wt | 313.405 | |
| Formula | C17H23N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yuichi Kajita, et al. J Med Chem. 2022 Feb 15.
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