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Chemical Structure : CH7233163
CAS No.: 2923365-71-1
Catalog No.: PC-38170Not For Human Use, Lab Use Only.
CH7233163 is a novel potent, selective mutant EGFR-Del19/T790M/C797S inhibitor with IC50 of 0.28 nM in biochemical assays.
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|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $558 | In stock | |
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| 100 mg | Get quote |
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CH7233163 is a novel potent, selective mutant EGFR-Del19/T790M/C797S inhibitor with IC50 of 0.28 nM in biochemical assays.
EAI-045, an allosteric EGFR inhibitor, didn't show inhibitory activity in this assay (IC50>1 uM).
CH7233163 potently inhibited the proliferation of Del19/T790M/C797S_NIH3T3 cells with IC50 of 20 nM, potently and dose dependently blocked the EGFR phosphorylation.
CH7233163 more selectively inhibits various types of EGFR mutants (e.g., L858R/T790M/C797S, L858R/T790M, Del19/T790M, Del19, and L858R) over wild type.
CH7233163 potently inhibited not only EGFR-Del19/T790M/C797S but also various EGFR mutations, including L858R/T790M/C797S triple mutations, double mutations and single-activating-mutations.
| M.Wt | 669.728 | |
| Formula | C31H34F3N9O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-5-isopropyl-7-(4-methylpiperazin-1-yl)-9-(2,2,2-trifluoroethoxy)-5H-pyrido[4,3-b]indol-3-amine |
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1. Kenji Kashima, et al. Mol Cancer Ther. 2020 Nov;19(11):2288-2297.
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