CHZ868 (CHZ-868) is a potent type II JAK2 inhibitor, inhibits the proliferation of SET2 JAK2 V617F cells (GI50=59 nM).
CHZ868 (CHZ868) reverses type I JAK inhibitor persistence and demonstrates efficacy in myeloproliferative neoplasms.
CHZ868 (CHZ868) reduces mutant allele burden in vivo, shows significant efficacy in Jak2V617F-driven polycythemia vera.
CHZ868 is orally active.
