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Chemical Structure : CK147
Catalog No.: PC-20794Not For Human Use, Lab Use Only.
CK147 (CK-147) is a potent CD4 down-modulator with IC50 of 63 nM, inhibits Sec61-dependent cotranslational translocation of huCD4 in vitro.
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CK147 (CK-147) is a potent CD4 down-modulator with IC50 of 63 nM, inhibits Sec61-dependent cotranslational translocation of huCD4 in vitro.
CK147 binds to a site near the plug domain and induces a partially opened conformation of Sec61.
CK147 markedly inhibits the cotranslational translocation of huCD4 in a cell-free in vitro translation assay with IC50 of 0.36 uM (HEK293T cells), with little impact on the ER import of preprolactin.
| M.Wt | 616.88 | |
| Formula | C32H48N4O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chawla R, et al. J Med Chem. 2016 Mar 24;59(6):2633-47.
2. Eva Pauwels, et al. Sci Adv. 2023 Mar 3;9(9):eadf0797.
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