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Chemical Structure : CL-387785
CAS No.: 194423-06-8
Catalog No.: PC-42524Not For Human Use, Lab Use Only.
CL-387785 (EKI785, WAY-EKI785) is a specific, irreversible, covalent EGFR inhibitor with IC50 of 0.37 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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CL-387785 (EKI785, WAY-EKI785) is a specific, irreversible, covalent EGFR inhibitor with IC50 of 0.37 nM.
CL-387785 blocks EGF-stimulated autophosphorylation of EGFR in A431 cells (IC50=5 nM).
CL-387785 inhibits cell proliferation (IC50= 31-125 nM) primarily in a cytostatic manner in cell lines that overexpress EGF-R or c-ErbB2, and profoundly blocks the growth of a tumor that overexpresses EGFR in nude mice; orally active.
| M.Wt | 381.226 | |
| Formula | C18H13BrN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 13.67 mg/mL |
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| Chemical Name/SMILES |
2-Butynamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]- |
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1. Discafani CM, et al. Biochem Pharmacol. 1999 Apr 15;57(8):917-25.
2. Kobayashi S, et al. Cancer Res. 2005 Aug 15;65(16):7096-101.
3. Kobayashi S, et al. Cancer Res. 2006 Dec 1;66(23):11389-98.
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