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Chemical Structure : CM-579
Catalog No.: PC-60256Not For Human Use, Lab Use Only.
CM-579 (CM579) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 16 nM and 32 nM for G9a and DNMT1, respectively.
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CM-579 (CM579) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 16 nM and 32 nM for G9a and DNMT1, respectively; also inhibits DNMT3A/3B with IC50 of 92/1,000 nM, respectively; inhibits cell proliferation and promotes apoptosis in different haematological neoplasias (AML, ALL and DLBCL).
| M.Wt | 492.664 | |
| Formula | C29H40N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. San José-Enériz E, et al. Nat Commun. 2017 May 26;8:15424.
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