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Chemical Structure : CMA-008
Catalog No.: PC-62062Not For Human Use, Lab Use Only.
CMA-008 is a cell-permeable, small molecule modulator of NAADP-mediated Ca2+ release, competes with NAADP binding, inhibit Ca2+ release via the NAADP receptor (IC50=15 uM-1 mM).
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CMA-008 is a cell-permeable, small molecule modulator of NAADP-mediated Ca2+ release, competes with NAADP binding, inhibit Ca2+ release via the NAADP receptor (IC50=15 uM-1 mM); selectively ablates NAADP-dependent Ca2+ oscillations induced by the external gastric peptide hormone agonist cholecystokinin (CCK) in murine pancreatic acinar cells.
| M.Wt | 308.075 | |
| Formula | C8H9IN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dowden J, et al. Chem Biol. 2006 Jun;13(6):659-65.
2. Dammermann W, et al. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10678-83.
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