CMM-98 | OGG1 activator | Probechem Biochemicals

Chemical Structure : CMM-98

CMM-98 (CMM98)

Catalog No.: PC-28421Not For Human Use, Lab Use Only.

CMM‐98 is a specific small molecule modulator / activator of DNA glycosylase OGG1 with AC50 of 38 nM and 83 nM on hOGG1 and mOGG1 respectively.

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Biological Activity

CMM‐98 is a specific small molecule modulator / activator of DNA glycosylase OGG1 with AC50 of 38 nM and 83 nM on hOGG1 and mOGG1 respectively.
CMM‐98 installs a robust AP‐site processing function in the DNA glycosylase OGG1 by binding the active site.
CMM‐98 effectively rewires the enzyme's catalytic outcome under oxidative stress, boosting AP site turnover by 57‐fold.
CMM‐98 reduces oxidative DNA damage burden, promotes the resolution of oxidative DNA lesions, and ameliorates hepatocyte injury.
CMM‐98 exhibits selectivity against representative DNA glycosylases and a wider kinase panel.

Physicochemical Properties

M.Wt	320.40
Formula	C18H20N6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-methyl-N4-phenyl-N2-(2-(pyridin-3-ylamino)ethyl)pyrimidine-2,4-diamine

References

1. Zhao Z, et al. Adv Sci (Weinh). 2026 Sep 27:e77956.

CMM-98 (CMM98)

Biological Activity

Physicochemical Properties

References

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