Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : CMP05
CAS No.:
Catalog No.: PC-72946Not For Human Use, Lab Use Only.
CMP05 (Endosomolytic compound CMP05) is a novel endosomolytic small-molecule compound that exhibits higher transfection efficiency/ability to induce endosomal escape of oligonucleotides (ONs) than current compounds such as chloroquine.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $458 | In stock | |
| 5 mg | $758 | In stock | |
| 10 mg | Get quote | ||
| 25 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
CMP05 (Endosomolytic compound CMP05) is a novel endosomolytic small-molecule compound that exhibits higher transfection efficiency/ability to induce endosomal escape of oligonucleotides (ONs) than current compounds such as chloroquine.
CMP05 had significantly higher efficacy than CMP01 at 5 uM, increased Splice-switching ON (SSO) activity.
CMP05 induced SSO leakage concurrently with endosomal swelling, induced SSO leakage in a mCherry-GAL9-recruitment-dependent manner.
CMP05 disrupted normal SSO trafficking through the endosomal network.
CMP05 was able to increase ON activity in a more efficacious manner than the previously published compound, UNC2383, in HeLa and HuH7 cell lines.
| M.Wt | 448.915 | |
| Formula | C22H21ClN8O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-(5-chloro-2-((3-methoxy-1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-1H-indole-4-carbonitrile |
|
1. Jeremy P Bost, et al. Commun Biol. 2022 Mar 1;5(1):185.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
