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Chemical Structure : CNBCA
Catalog No.: PC-20975Not For Human Use, Lab Use Only.
CNBCA is a selective, competitive inhibitor of Src homology phosphotyrosyl phosphatase 2 (SHP2) with IC50 of 0.87 uM, effectively suppresses breast cancer cell phenotypes.
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CNBCA is a selective, competitive inhibitor of Src homology phosphotyrosyl phosphatase 2 (SHP2) with IC50 of 0.87 uM, effectively suppresses breast cancer cell phenotypes.
CNBCA shows good selectivity (>25-fold) over SHP1 and PTP1B in the phosphatase assays.
CNBCA binds to endogenous full-length SHP2 under cellular contexts, inhibits FL-SHP2 with IC50 of 0.615 uM in PTPase assays.
CNBCA effectively downregulates SHP2 mediated signaling in breast cancer (BC) cells, inhibits SHP2 mediated Akt and ERK1/2 activation in the BT474 and MDA-MB468 cells with IC50 of 1 uM.
CNBCA (500 nM) is effective in suppressing the cancer stem cell properties of BC cells.
| M.Wt | 426.55 | |
| Formula | C26H34O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dhanaji M. Lade, et al. ACS Bio Med Chem Au 2023
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