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CNS-11

Chemical Structure : CNS-11

CAS No.: 445218-34-8

CNS-11

Catalog No.: PC-49766Not For Human Use, Lab Use Only.

CNS-11 is a small molecules capable of disassembling preformed alpha-synuclein fibrils, may exert it's disaggregating effects on the N terminus of the fibril core.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CNS-11 is a small molecules capable of disassembling preformed alpha-synuclein fibrils, may exert it's disaggregating effects on the N terminus of the fibril core.
CNS-11 is more predictive of oral bioavailability and central nervous system penetration compared to EGCG.
CNS-11 (10 uM) inhibits intracellular seeding in alpha-synuclein biosensor cells and mitigation of alpha-synuclein cytotoxicity.
CNS-11 disaggregates MSA patient brain-derived alpha-synuclein fibrils in vitro, reduces alpha-synuclein aggregates in C. elegans, also could penetrate brain tissue in mice.

Physicochemical Properties

M.Wt 395.46
Formula C25H21N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-mesityl-2-(3-oxoindeno[1,2,3-de]phthalazin-2(3H)-yl)acetamide

References

1. Murray KA, et al. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2217835120.

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