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Chemical Structure : CO-1686
CAS No.: 1374640-70-6
Catalog No.: PC-44666Not For Human Use, Lab Use Only.
Rociletinib (CO1686, AVL-301, CNX-419) is a potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $28 | In stock | |
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote |
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Rociletinib (CO1686, AVL-301, CNX-419) is a potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M.
Rociletinib shows 22-fold selective over WT EGFR; EGFR del19, T790M, L858R/T790M and L858R mutant kinases demonstrates the highest degree of inhibition at 0.1 uM; orally bioavailable.
| M.Wt | 555.5515 | |
| Formula | C27H28F3N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 43 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]- |
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1. Walter AO, et al. Cancer Discov. 2013 Dec;3(12):1404-15.
2. Tjin Tham Sjin R, et al. Mol Cancer Ther. 2014 Jun;13(6):1468-79.
3. Sequist LV, et al. N Engl J Med. 2015 Apr 30;372(18):1700-9.
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