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Chemical Structure : CO-1686 hydrobromide
CAS No.: 1446700-26-0
Catalog No.: PC-44667Not For Human Use, Lab Use Only.
A potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $64 | In stock | |
| 50 mg | $132 | In stock | |
| 100 mg | $204 | In stock |
Bulk size, bulk discount!
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A potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M; shows 22-fold selective over WT EGFR; EGFR del19, T790M, L858R/T790M and L858R mutant kinases demonstrates the highest degree of inhibition at 0.1 uM; orally bioavailable.
Breast Cancer
Phase 2 Clinical
| M.Wt | 636.4634 | |
| Formula | C27H29BrF3N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 59 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-, hydrobromide (1:1) |
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1. Walter AO, et al. Cancer Discov. 2013 Dec;3(12):1404-15.
2. Tjin Tham Sjin R, et al. Mol Cancer Ther. 2014 Jun;13(6):1468-79.
3. Sequist LV, et al. N Engl J Med. 2015 Apr 30;372(18):1700-9.
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