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Chemical Structure : CP-100356 hydrochloride
Catalog No.: PC-72608Not For Human Use, Lab Use Only.
CP-100356 hydrochloride (CP100356) is a specific P-glycoprotein (P-gp) inhibitor, suppresses VSV-LASVGP, LCMV, and LASV infection with IC50 of 0.52, 0.54, and 0.062 uM, respectively, without significant cytotoxicity.
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CP-100356 hydrochloride (CP100356) is a specific P-glycoprotein (P-gp) inhibitor, suppresses VSV-LASVGP, LCMV, and LASV infection with IC50 of 0.52, 0.54, and 0.062 uM, respectively, without significant cytotoxicity.
CP100356 did not block receptor binding at the cell surface, it inhibited low-pH-dependent membrane fusion mediated by arenavirus glycoproteins.
CP-100356 is an in vivo probe to selectively assess MDR1/BCRP-mediated drug efflux was examined in the rat.
CP-100356 inhibited acetoxymethyl calcein (calcein-AM) uptake (IC50= 0.5 uM) and digoxin transport (IC50=1.2 uM) in human MDR1-transfected MDCKII cells.
| M.Wt | 597.109 | |
| Formula | C31H37ClN4O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Takenaga T, et al. Viruses. 2021 Sep 3;13(9):1763.
2. Kalgutkar AS, et al. J Pharm Sci. 2009 Dec;98(12):4914-27.
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