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Chemical Structure : CP-339818
CAS No.: 478341-55-8
Catalog No.: PC-62919Not For Human Use, Lab Use Only.
CP-339818 is a potent, selective, non-peptide KV1.3 channel antagonist with IC50 of 200 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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CP-339818 is a potent, selective, non-peptide KV1.3 channel antagonist with IC50 of 200 nM.
CP-339818 displays selectivity over Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2, with only exception Kv1.4 (IC50=300 nM), also has no effect on T cell channels (I(CRAC) and intermediate-conductance K(Ca)).
CP-339818 inhibits Kv1.3 in a use-dependent manner by preferentially blocking the C-type inactivated state of the channel; suppresses human T cell activation.
| M.Wt | 340.895 | |
| Formula | C21H25ClN2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[1-(Phenylmethyl)-4(1H)-quinolinylidene]-1 pentanamine hydrochloride |
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1. Nguyen A, et al. Mol Pharmacol. 1996 Dec;50(6):1672-9.
2. Jäger H, et al. J Physiol. 1998 Jan 15;506 ( Pt 2):291-301.
3. Lee YT, et al. Eur J Pharmacol. 2008 Feb 26;581(1-2):97-104.
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